Annual report pursuant to Section 13 and 15(d)

Commitments (Details Narrative)

v3.8.0.1
Commitments (Details Narrative) - USD ($)
 1 Months Ended 12 Months Ended
Dec. 15, 2016
Nov. 10, 2016
Sep. 12, 2016
Sep. 12, 2016
Feb. 18, 2016
Aug. 31, 2017
Nov. 01, 2013
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Lease term 10 years           7 years      
Operating leases rent expense $ 43,000           $ 12,723 $ 504,000 $ 244,000 $ 212,000
Increase decrease in lease rental expense $ 64,000           $ 14,200      
Lease expiration date Aug. 01, 2017                  
Revenue recognition, milestone fee on achieving sales threshold               $ 100,000    
Finance Agreement [Member]                    
Debt instrument, term           9 months        
Debt instrument, face amount           $ 383,030        
Debt instrument, maturity date           Apr. 10, 2018        
Debt instrument, interest rate, stated percentage           2.25%        
Debt instrument, periodic payment, interest           $ 42,959        
Series A Preferred Stock [Member]                    
Debt instrument, interest rate, stated percentage               8.00%    
Accrued royalties     $ 35,000,000 $ 35,000,000            
Royalty payment rights expire year     2033              
Minimum [Member]                    
License costs               $ 10,000    
Maximum [Member]                    
License costs               $ 50,000    
Maximum [Member] | Series A Preferred Stock [Member]                    
Royalty percentage       7.50%       7.50%    
Proceeds from royalty       $ 10,000,000            
Maximum [Member] | Series A Preferred Stock [Member] | Sales Revenue, Net [Member]                    
Royalty percentage       4.50%       4.50%    
Proceeds from royalty       $ 25,000,000            
Office Lease [Member]                    
Security deposit               $ 300,000    
Security deposits reduced by straight line basis description               This deposit was reduced by $100,000 in 2016 and 2015 and can be reduced down to $50,000 in 2018, as long as the Company makes timely rental payments.    
Laboratory and Facility [Member]                    
Security deposit               $ 586,000    
Security deposits reduced by straight line basis description               This security deposit can be reduced $100,000 on each of the first three anniversaries of the rent commencement date. On the fourth anniversary, it can be reduced another $86,000, with the balance over the remaining life of the lease.    
Research and Development Agreement [Member]                    
Other commitment         $ 200,000          
Debt instrument, term         3 years          
Travel expenses   $ 132,568