Annual report pursuant to Section 13 and 15(d)

Commitments (Details Narrative)

v3.19.1
Commitments (Details Narrative) - USD ($)
 12 Months Ended
Dec. 15, 2016
Sep. 12, 2016
Feb. 19, 2016
Oct. 29, 2015
Nov. 01, 2013
Dec. 31, 2018
Dec. 31, 2017
Nov. 07, 2018
Operating leases rent expense           $ 745,000 $ 504,000  
Other commitment               $ 150,000
Revenue recognition, milestone fee on achieving sales threshold           100,000    
License costs           10,000    
Maximum [Member]                
License costs           $ 50,000    
Series A Preferred Stock [Member]                
Accrued royalties   $ 35,000,000            
Royalty percentage   4.50%       7.50%    
Proceeds from royalty   $ 25,000,000            
Royalty payment rights expire year   2033            
Series A Preferred Stock One [Member]                
Royalty percentage   7.50%            
Proceeds from royalty   $ 10,000,000            
Cooperative Research and Development [Member]                
Funds provide for support     $ 200,000 $ 132,405        
Initial term     3 years 3 years        
Other commitment     $ 200,000          
June 2014 [Member]                
Lease term         7 years      
Operating leases rent expense         $ 13,000      
Increase in lease rental expense         $ 14,000      
August 1, 2017 [Member]                
Lease term 10 years 3 months              
Operating leases rent expense $ 43,000              
Increase in lease rental expense $ 64,000