Annual report pursuant to Section 13 and 15(d)

Stock-based Compensation (Details Narrative)

v3.22.0.1
Stock-based Compensation (Details Narrative) - USD ($)
12 Months Ended
May 08, 2014
Dec. 31, 2021
Dec. 31, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based payment award increase of shares offering date January 1, 2015    
Share-based Compensation Arrangement by Share-based Payment Award, Percentage of Outstanding Stock Maximum 4.00%   4.00%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number   14,625,397  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value   $ 1.20  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value   $ 2,500  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Grant Date Intrinsic Value   $ 1.01  
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount   $ 11,700,000  
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition   2 years 10 months 24 days  
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights   All outstanding options expire ten years from date of grant. Options granted to employees prior to 2018 vest in equal monthly installments over three years. Beginning in 2018, options granted to employees vest over four years, with 25% of the shares vesting on the first annual anniversary of grant and the remaining shares vesting in 36 equal monthly installments over the following 3 years. A portion of options granted to consultants vests over four years, with the remaining vesting being based upon the achievement of certain performance milestones, which are tied to either financing or drug development initiatives.  
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period   10 years  
Stock Issued During Period, Shares, Restricted Stock Award, Gross   31,769 379,385
Other General and Administrative Expense   $ 100,000 $ 292,000
Share-based Payment Arrangement, Option [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage   25.00%  
2013 Equity Compensation Plan [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based Compensation Arrangement by Share-based Payment Award, Description   granted at prices not less than 100% of the fair value of the shares  
Share-based Compensation Arrangement by Share-based Payment Award, Terms of Award   The term of the options is no longer than ten years  
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized   36,952,460  
2013 Equity Compensation Plan [Member] | Minimum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period   3 years  
2013 Equity Compensation Plan [Member] | Maximum [Member]      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period   4 years