Quarterly report pursuant to Section 13 or 15(d)

Commitments (Details Narrative)

v3.8.0.1
Commitments (Details Narrative) - USD ($)
 1 Months Ended 3 Months Ended
Dec. 15, 2016
Nov. 10, 2016
Sep. 12, 2016
Feb. 18, 2016
Aug. 31, 2017
Nov. 01, 2013
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Lease term 10 years         7 years      
Lease expiration date Aug. 01, 2017                
Operating leases rent expense $ 43,000         $ 12,723 $ 186,000 $ 103,000  
Increase decrease in lease rental expense $ 64,000         $ 14,200      
Security deposit             155,457   $ 155,431
Current assets             4,893,867   $ 7,963,970
Revenue recognition, milestone fee on achieving sales threshold             $ 100,000    
Series A Preferred Stock [Member]                  
Debt instrument, interest rate, stated percentage             8.00%    
Royalty percentage     7.50%       7.50%    
Proceeds from royalty     $ 10,000,000       $ 10,000,000    
Royalty payment rights expire year     2033            
Series A Preferred Stock [Member] | Sales Revenue, Net [Member]                  
Royalty percentage     4.50%       4.50%    
Proceeds from royalty     $ 25,000,000       $ 25,000,000    
Minimum [Member]                  
License costs             10,000    
Maximum [Member]                  
License costs             50,000    
Maximum [Member] | Series A Preferred Stock [Member]                  
Accrued royalties     $ 35,000,000            
Cooperative Research and Development Agreement [Member]                  
Other commitment       $ 200,000          
Debt instrument, term       3 years          
Travel expenses   $ 132,568              
Finance Agreement [Member]                  
Debt instrument, term         9 months        
Debt instrument, face amount         $ 383,030        
Debt instrument, maturity date         Apr. 10, 2018        
Debt instrument, interest rate, stated percentage         2.25%        
Debt instrument, periodic payment, interest         $ 42,959        
Office Lease [Member]                  
Security deposit             $ 300,000    
Security deposits reduced by straight line basis description             This deposit was reduced by $100,000 in 2016 and 2015 and reduced down to approximately $105,457(including interest) in 2018 ($ 55,457 was collected in April of 2018).    
Long term asset             $ 50,000    
Laboratory and Facility [Member]                  
Security deposit             $ 586,000    
Security deposits reduced by straight line basis description             This security deposit can be reduced $100,000 on each of the first three anniversaries of the rent commencement date. On the fourth anniversary, it can be reduced another $86,000, with the balance over the remaining life of the lease.    
Current assets             $ 100,000