Annual report pursuant to Section 13 and 15(d)

Stock-based Compensation - Schedule of Recognized Stock-Based Compensation (Details)

v3.19.1
Stock-based Compensation - Schedule of Recognized Stock-Based Compensation (Details) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Share-based compensation expense $ 3,833,000 $ 3,597,000
Research and Development [Member]    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Share-based compensation expense 896,000 1,016,000
General and Administrative [Member]    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Share-based compensation expense $ 2,937,000 $ 2,581,000